1. 1We propose a multi-sample synthetic process based on ordinary organic synthesis.

   We conduct studies related to parallel liquid-phase synthesis, solid-state synthesis, purification methods, and proposal of synthetic pathways.

2. 2Library Synthesis

   Proceeding with production in accordance with the efficiently optimized synthetic processes.

3. 3Library Purification

   Improving the product quality by purification using liquid-phase preparatory equipment, solid-phase reagents, MS-triggered chromatography systems, etc.

4. 4Quality Control

   Structural and purity analyses of the samples are conducted using LC/MS, NMR, and HPLC. Samples are delivered in the requested form.

5. 5Delivery

Library synthesis reaction: example 1

Example1: amidation

Delivered amount	20-mg plus minimum with more than 90% purity 1000 compounds/3 months A reaction success rate of more than 90%

Example2: Suzuki coupling

Delivered amount	10-mg plus minimum with more than 95% purity 100 compounds/1 month A reaction success rate of more than 90%

Library synthesis reaction: example 2

Library synthesis results based on the FTE contract

Short-term contract (1 to 2 projects)

Synthesis of 100–400 compounds per month (including library synthesis study)

Long-term contract (multiple projects)

Synthesis of 150–400 compounds per month (including library synthesis study)

The flow of basic FFS contracts

1. 1

   Library synthesis
   Preliminary study

2. 2

   Library synthesis

3. 3

   LC–MS separation
   Purification

4. 4

   QC(LC-MS)

Basic conditions for conducting separation and analysis

Main equipment for conducting parallel synthesis