Dopamine
| Order number | PP022-0 |
|---|---|
| Name | PE2I |
| Chemical Formula | C19H24INO2 |
| Molecular Weight | 425.31 |
| Purity | > 95% |
| Packaging | min. 10 mg, or as ordered |
| Purpose | Reference standard for [11C]PE2I and for [123I]PE2I |
| Other name | N-(3-iodoprop-2E-enyl)-2-β-carbomethoxy-3-β-(4’-methylphenyl)nortropane ; Methyl 8-[(2E)-3-iodoprop-2-en-1-yl]-3-(4-methylphenyl)- 8-azabicyclo[3.2.1]octane-2-carboxylate |
| CA index name | 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-3-iodo-2-propenyl]-3-(4-methylphenyl)-, methyl ester, (1R, 2S, 3S, 5S)- |
| Literature | 1. Guilloteau D, Emond P, Baulieu JL, Garreau L, Frangin Y, Pourcelot L, Mauclaire L, Besnard JC, Chalon S. Exploration of the dopamine transporter: in vitro and in vivo characterization of a high-affinity and high-specificity iodinated tropane derivative (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (PE2I). Nucl Med Biol. 1998; 25(4):331-7. 2. Poyot T, Condé F, Grégoire MC, Frouin V, Coulon C, Fuseau C, Hinnen F, Dollé F, Hantraye P, Bottlaender M. Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa. J Cereb Blood Flow Metab. 2001;21(7):782-92 3. Schwarz J, Storch A, Koch W, Pogarell O, Radau PE, Tatsch K. Loss of dopamine transporter binding in Parkinson's disease follows a single exponential rather than linear decline. J Nucl Med. 2004; 45(10):1694-7. |
