Phosphodiesterase-4 (PDE4)
| Order number | NP057-0 |
|---|---|
| Name | (R)-(-)-Rolipram |
| Chemical Formula | C16H21NO3 |
| Molecular Weight | 275.35 |
| Purity | > 95% |
| Packaging | min. 10 mg, or as ordered |
| Purpose | Reference standard for (R)-(-)-[11C] Rolipram |
| Other name | (R)- Rolipram; (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |
| CA index name | 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- |
| Literature | 1. DaSilva J.N., Lourenco C.M., Meyer J.H., Hussey D., Potter W.Z., Houle S. Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography. Eur J Nucl Med Mol Imaging. 2002; 29(12):1680-3. 2. Fujita M, Zoghbi SS, Crescenzo MS, Hong J, Musachio JL, Lu JQ, Liow JS, Seneca N, Tipre DN, Cropley VL, Imaizumi M, Gee AD, Seidel J, Green MV, Pike VW, Innis RB. Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET. Neuroimage. 2005; 26(4):1201-10. 3. Tsukada H., Harada N., Ohba H., Nishiyama S., Kakiuchi T. Facilitation of dopaminergic neural transmission does not affect [11C]SCH23390 binding to the striatal D1 dopamine receptors, but the facilitation enhances phosphodiesterase type-IV activity through D1 receptors: PET studies in the conscious monkey brain. Synapse. 2001; 42(4):258-65. |
