NARD Institute technical keywords

Custom Synthesis Service

Sample Synthesis, Experimental Synthesis
·Organic Chemistry  ·Inorganic Chemistry  ·Polymer Chemistry  ·Combinatorial Synthesis
Synthetic Procedure Studies
·Purification Techniques  ·Synthetic Route Investigation  ·Flow Synthesis
Synthetic Process Development
·Scale-up Feasibility Studies  ·Process Refinement Studies  ·GMP-compliance Studies
·FTE Services
·NARD Chemicals

1. Sample Synthesis, Experimental Synthesis

Custom one-off organic synthesis
We will consider any organic reaction

Suzuki coupling Buchwald amination Heck reaction Stille coupling
Sonogashira coupling Ullmann coupling Negishi coupling Mitsunobu reaction
Mannich reaction Wittig reaction Horner–Wadsworth–Emmons (HWE) reaction Grignard reaction
Gabriel synthesis Jones oxidation Michael addition Simmons‐Smith
Williamson ether synthesis Heterocyclic compound synthesis Catalytic hydrogenation NaBH4reduction
LiAlH4reduction Condensation reaction Olefin metathesis Etc.

Examples of the contract chemical library synthesis using combinatorial technique.

Custom macromolecule synthesis

10 L scale ambient pressure reactor
'Three-One Motor' agitator
Nitrogen flow tube
Nitrogen flow meter
Stirring blade
Nitrogen cylinder
Thermocouple No.1
10 L separable flask
Solvent trap
Mantle heater
Thermocouple No.2
Temperature control x2
Pressure reactor
Dehydration and deoxygenation reactions

Custom ceramic synthesis (example of solid-phase process)

Weighing and mixing
Mixing is performed with a mortar, planetary ball-mill, SC mill, etc.
Gases released during the reaction may damage the sample integrity, so this preliminary firing is performed to remove volatile materials.
The mixture is mechanically pressed into pellet form
Firing is performed with a muffle furnace or an atmosphere-controlled tubular furnace (max. 1500℃)
Pulverization and analysis
Pulverization is performed with a mortar or planetary ball-mill. Characterization is by x-ray diffraction, and composition ratio analysis by ICP.

2. Synthetic Procedure Studies

Continuous-flow Synthesis

Various conditions are investigated to establish a process for continuous-flow synthesis, allowing production of the target compound from gram-scale to kilogram-scale.

Between the microreactor and the CSTR, reaction times from a few milliseconds to several hours can be accommodated. If necessary, batch synthesis steps may also be integrated into the process.

Purification of organic compounds

  • Recrystallization
    ·Cooling method
    ·Poor solvent addition method
    ·Evaporation method
    ·Solvent choice
    ·Management of impurities
  • Distillation
    ·Simple distillation
    ·Precision distillation
    ·Vacuum distillation

  • Chromatography
    ·Open column
    ·Preparative HPLC
    ·Recycling GPC
  • Sublimation
    ·Vacuum sublimation
    ·Thermal gradient (train) sublimation
    ·Vapour-phase crystal growth
  • Clean Environment
    ·Clean booth
    ·Cleanroom, class 10,000
    ·Clean draft, class 100

3. Synthetic Process Development

FTE (contracted hours) research

Outline of the request
·General purpose and specific objectives  ·Existing procedures and current progress
Creation of a specification
·Fields of investigation  ·Schedule etc.
·Emphasis on communication  ·Research proposal
·Weekly, Monthly  ·Final report

Example of FTE research

Selection of feedstock Investigation of bulk-importation of feedstock, management of contracted feedstock production
Study of reaction conditions Investigation of synthetic methods for mass-production, yield improvement, danger minimization, inhibition of by-products, cost-reduction
Isolation and purification studies Avoidance of chromatography, crystallization studies, improvement of purity, management of impurities
Configuration of quality control systems Determination of intermediate and final product QC methods, validation of analytical procedures
GMP-compliant pharmaceutical production Reaction and handling process feasibility studies, impurity management, standardization of feedstock and key intermediates

4. Manufacturing

ISO9001 and GMP-compliant manufacturing facility, NARD Chemicals

Equipped to scale-up experimental procedures to production levels.

  • Reaction stage
    Reaction stage
    Separable reactor may be configured for reactions between 30 and 400 L
    Maximum reaction capacity: 3000 L
  • Processing stage
    Processing stage
    Drying is performed in a 100 L evaporator
  • Purification stage
    Purification stage
    200 L silica gel column chromatography
There are many more examples of our achievements and capabilities. Please feel free to inquire.
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