With NARD's contract synthesis, contract manufacture, and contract research services, we will help you overcome challenges in research and development.
We have proven experience of research and development in many fields, including pharmaceuticals, organic electroluminescent materials, organic semiconductors, and battery materials.
With its system of high-quality assurance, NARD Chemicals has the flexibility to offer an optimal response over a wide range of contract manufacturing scenarios, from initial development to final product.
·Specialization in job-shop manufacturing: small quantities of many products
·Utilization of each employee's high technical expertise
·Quality assurance that lives up to your expectations (GMP, ISO9001)
We have the experience and equipment to handle a wide variety of reactions.
Below -100℃, reactions possible up to 400 L
Above 200℃, reactions possible up to 500 L
·Inhibited decomposition of unstable intermediates
·Grignard reaction, etc. (activation of organometallic reagents)
·LiAlH4, Et3Al, etc. (flammable and pyrophoric reagents)
Extraction systems for odor management of sulfur-based reagents
·Swern reaction, etc. (odorous reactions)
·Use of various thiols
By controlling oxygen contamination, we deliver reliable results for sensitive reactions.
·Oxygen concentration management for Pd(0) catalyzed reactions
(Suzuki, Negishi coupling, etc.)
The risk of thermal runaway, explosion, etc. is evaluated in advance to determine feasibility.
·Use of peroxides in oxidation reactions, etc.
·Management of polymerizations
Nucleophilic substitution and addition of nitrile anions under basic conditions
With a small trial reactor, test runs of plant-production are performed.
Reproducing laboratory conditions as closely as possible, the reactions are scaled up.
·Modular reaction vessel
·Highly flexible reactions equipment
·Variety of stirring blades
·Wide range of reaction temperatures (-100 –+250℃)
·Standard plant-production equipment
·Glass-lined and SUS equipment
·Suitable for high-pressure hydrogenation
400, 260, 200, 100, 30 L (total: 11)
Suitable temperature:–100 –+250℃
1600 (max. 9.9 atm), 1500, 500 L (total: 4)
Suitable temperature: -15 –+120℃
200, 100, 50 L (total: 13)
Suitable temperature: -40 –+200℃
3000, 1500, 1000, 500 L (total: 8)
Suitable temperature: -5 –+120℃
50, 100, 200, 260 L columns
SUS with visualization slit
Temperature control jacket
Pressurized flushing possible
Many gels available
(various silica gels, ODS, adsorption resins, etc.)
·Precision preparative purification
·Desalting and purification by ion exchange and adsorption gels
·In cases where development-stage column chromatography cannot be avoided
100L 100 L evaporator (explosion-proof) x4
Capable of drying up to 30 kg
·Viscous oil isolation
·Dry product crystal isolation
Used for concentration of heat-sensitive materials
·Concentration of fermentation products
·Processing extracts of natural products, herbal medicines, etc.
·Concentration of samples for food product development
·Other thermally unstable materials
Concentration capacity: 200 L / h (aq. solution)
Heater contact time: 1 sec
Class 10000 managed
Glass-lined filtration machine
Glass-lined reactors (100, 200 L)
SUS-shelving vacuum desiccator (5.5 m2)
Class 100k managed
Clean space for use with general equipment(16 m2)
e.g. 400 L reactor, portable centrifuge, etc.
HPLC x10, GC x3
HPLC x9 (two units with integrated PDA detector), LC/MS x1, GC x3
HPLC (UV, PDA, RI, GPC), GC (FID)
Karl Fischer titrator (volumetric, coulometric), IR spectrometer, UV-Vis spectrometer, polarimeter, autotitrator, particle-size distribution analyzer, atmospheric control system
Development of synthetic procedures that may be rapidly adapted from laboratory application to plant production.
·Development of GMP-compliant production processes
·Optimization of parameters and verification of threshold values
·Proposals of new production methods for mass-production
·Process safety verification
·Investigation and validation of reasonable manufacturing costs
As well as the product sample, a detailed study of the manufacturing process is also included with the final report.