NARD Institute technical keywords

PET = Positron Emission Tomography

We strongly support the research and development of PET chemicals.

Sales for PET Chemicals

We have a wide-ranged product line-up in stock.
The minimum amount for ordering is 10mg. Most of our PET / SPECT Chemicals purity is higher than 98%. The delivery time of our PET Chemicals in stock will be short. All our products are provided with the certification of analysis including HPLC charts, 1H-NMR spectra data and so on.
The items listed in the Catalogue (PET/SPECT) will be updated at any time. Please contact us by E-mail.

Chemical List (precursors & referential standard compounds)
PET chemicals
Acetylcholine :
NP034-0 :
(+)3-MPB
NP034-1 :
(+)3-PB
NP035-0 :
(-)3-MPB
NP035-1 :
(-)3-PB
NP059-0 :
(+)3-EPB
NP060-0 :
(+)3-PPB
NP042-0 :
Donepezil
NP042-1 :
Desmethyl-donepezil
NP072-0 :
MP4A
NP072-1 :
P4A
NP073-0 :
MP4P
NP073-1 :
P4P
Adenosine A2A :
PP027-0 :
TMSX
PP027-1 :
Desmethyl-TMSX
Benzodiazepine :
PP010-0 :
(R) –PK11195
PP010-1 :
(R) -N-Desmethyl PK11195
PP011-0 :
Flumazenil
PP011-1 :
Desmethyl-flumazenil
PP011-2 :
Nitro-flumazenil
PP046-0 :
PBR 28
PP046-1 :
O-Desmethyl-PBR 28
NP065-0 :
DAA1106
NP065-1 :
Desmethyl-DAA1106
NP066-0 :
FEDAA1106
NP067-0 :
AC-5216
NP067-1 :
Desmethyl- AC-5216
NP068-0 :
FEAC
NP069-0 :
DAC
NP069-1 :
Desmethyl- DAC
NP070-0 :
FEDAC
Dopamine :
PP003-0 :
6-Fluoro-L-DOPA
PP003-2 :
4-O-Pivaloyl-L-DOPA
PP003-3 :
Sn-L-DOPA
PP004-0 :
(R)-(+)-SCH-23390
PP004-1 :
SCH-24518
PP005-0 :
Raclopride
PP005-1 :
Desmethyl-raclopride
PP006-0 :
FLB 457
PP006-1 :
FLB 604
PP007-0 :
NNC 112
PP007-1 :
Desmethyl-NNC 112
PP008-0 :
Fallypride
PP008-1 :
Tosyl-fallypride
PP009-1 :
N-Mesitylenesulfonyloxy-ethyl-spiperone
PP019-0 :
β-CFT
PP019-1 :
nor-β- CFT
PP020-0 :
β-CIT
PP020-1 :
nor -β- CIT
PP021-0 :
β-CPT
PP022-0 :
PE2I
PP022-1 :
Desmethyl-PE2I
PP045-0 :
Fluoroethyl-PE2I
PP045-1 :
Tosylethyl-PE2I
PP023-0 :
β-CIT-FE
PP023-1 :
β-CIT-FES
PP024-0 :
β-CIT-FP
PP030-0 :
MNPA
PP030-1 :
TNPA
PP030-2 :
TNPA acetonide
Histamine :
PP033-0 :
Doxepin
PP033-1 :
Desmethyl-Doxepin
Amyloid ;
NP039-0 :
BF-227
NP039-1 :
THK-001
PP043-0 :
6-MeO-BTA-0
PP044-0 :
6-OH-BTA-1
PP044-1 :
6-OH-BTA-0
Tau ;
NP076-0 :
PBB3
NP076-1 :
Pre3
NP076-2 :
DMPBB3
Aromatase :
PP048-0 :
Vorozole
PP048-1 :
Desmethyl-Vorozole
Amino Acid :
PP016-0 :
L-Homocysteine
PP016-1 :
L-Homocysteine thiolactone HCl
PP058-1 :
D-Homocysteine thiolactone HCl
PP018-0 :
L-2-Fluoro- tyrosine
PP018-1 :
2-SnT
NP050-0 :
FAMT
NP050-1 :
AMT
NP053-0 :
FMT
NP053-1 :
2-SnMT
NP075-0 :
L-FBPA
NP061-1 :
L-BPA
Estrogen :
NP071-1 :
MMSE
Hypoxia :
NP036-0 :
FMISO
NP036-1 :
NITTP
NP051-0 :
FAZA
NP051-1 :
Tosyl-FAZA
NP052-0 :
CuATSM
NP052-1 :
ATSM
Monoamine Oxidase :
PP028-0 :
L-Deprenyl
PP028-1 :
Desmethyl- L-Deprenyl
PP029-0 :
D2-(R)-Deprenyl
PP029-1 :
D2-(R)-Desmethyl-deprenyl
Norepinephrine :
PP031-0 :
MeNER
PP032-0 :
FD2-MeNER
PP032-1 :
NER
μ-Opioid :
PP017-0 :
Carfentanil
PP017-1 :
Desmethyl carfentanil
DNA synthesis :
NP002-0 :
FLT
NP002-1 :
Anhydrothy·ine
NP002-2 :
Boc-thy·ine
PP002-3 :
DB-thy·ine
NP049-0 :
4DST
NP049-1 :
Sn- 4DST
Glucose Metabolism :
PP001-0 :
FDG
PP001-1 :
Mannose triflate
Serotonin (5HT) :
PP012-0 :
Altanserin
PP012-1 :
Nitro-Altanserin
PP013-0 :
Setoperone
PP013-1 :
Nitro-Setoperone
PP014-0 :
MDL100907
PP014-1 :
Desmethyl-MDL100907
PP015-0 :
WAY100635
PP015-1 :
WAY100634
PP025-0 :
DASB
PP025-1 :
Desmethyl-DASB
PP026-0 :
MADAM
PP026-1 :
N-Desmethyl-MADAM
NP037-0 :
(+)-McN5652
NP037-1 :
pre-(+)-McN5652
NP038-0 :
(-)-McN5652
NP038-1 :
pre-(-)-McN5652
Vesicular monoamine transpoter2 :
PP040-0 :
FE- (+)-DTBZ
PP041-0 :
(+)-DTBZ
PP041-1 :
(+)-9-O-Desmethyl-DTBZ
cannabinoid (CB-1) :
PP047-0 :
MePPEP
PP047-1 :
Desmethyl-MePPEP
P-glycoprotein :
NP054-0 :
(+)-Verapamil
NP054-1 :
(+)-Norverapamil
NP055-0 :
(-)-Verapamil
NP055-1 :
(-)-Norverapamil
Phosphodiesterase-4(PDE4)) :
NP056-0 :
(S)-(+)-Rolipram
NP056-1 :
(S)-(+)-Desmethyl-Rolipram
NP057-0 :
(R)-(-)-Rolipram
NP057-1 :
(R)-(-)-Desmethyl-Rolipram
NMDA :
PP074-0 :
CNS5161
PP074-1 :
Desmethyl- CNS5161
Ligands for SPECT imaging
PS001-0 :
Epidepride
PS001-1 :
Tributyltinyl-epidepride
PS002-1 :
Trimethyltin-β-CIT
PS003-1 :
Tributyltin-PE2I
PS004-0 :
ADAM
PS004-1 :
Tributyltin- ADAM
PS005-0 :
NNC 13 8341
PS005-1 :
Trimethyltin-NNC 13 8341
Chemicals for Synthesize
NC001-0 :
Fluoromethyl tosylate
NC002-0 :
Fluoroethyl tosylate
NC004-0 :
2-Bromoethyl triflate
NC005-0 :
TABT
NC003-0 :
LAH 0.1M-0.5mL
NC003-1 :
LAH 0.1M-1mL
NC003-2 :
LAH 0.25M-0.5mL
NC006-0 :
HI 1mL

Custom Synthesis

One of our most important service for the clients is Custom Synthesis. We are able to offer specially-ordered compounds for PET / SPECT. Regarding an inquiry for any reagent that is not listed in the Catalogue, it is possible to receive as a special order.

GMP service

We also have experiences to manufacture PET chemicals in accordance with Good manufacturing practice (GMP) standard in NARD Chemicals, Ltd., which is our subsidiary company.

Topics

Catalogue No. NP034-0

Effect of Aging on Muscarinic Receptors in the Monkey Brain as Measured by [11C] (+)3-MPB
*Image Data of products jointly developed by Hamamatsu Photonics K.K.

Tsukada et al., Synapse (2001a, b); Nishiyama et al., Synapse (2001)

Catalogue No. NP076-0

Start the exclusive sales of PBB3 (new PET ligands of tau pathology)

We are proud to announce that we concluded an exclusive licensing agreement for commercialization of PBB3, Pre3 and DMPBB3 with National Institute of Radiological Sciences (NIRS).
Three compounds, which are referential standard compounds and precursor, are now able to be supplied only in research applications from NARD Institute, Ltd..
We hope that studies for PET of tau pathology becomes more active through the use of [11C]PBB3.

Structure of PBB3, Pre3 and DMPBB3

[11C]PBB3 ([11C]pyridinyl-butazienyl-benzothiazole; IUPAC name, 2-((1E,3E)-4-(6-([11C]methylamino)pyridin-3-yl)buta-1,3-dienyl)benzo[d]thiazol-6-ol) is a radioactive compound applicable to positron emission tomography (PET) imaging of tau protein aggregates in living brains.1) Tau lesions, as exemplified by neurofibrillary tangles in Alzheimer’s disease (AD), are characteristic of diverse neurodegenerative dementias, and are known to tightly correlate with neuronal death in these illnesses. [11C]PBB3 reacts with tau deposits in AD with high affinity (KD = 2.5 nM) and selectivity (tau : Aβ = 120 : 1) according to an autoradiographic binding assay.1) Using an established radiolabeling protocol,2) [11C]PBB3 can be synthesized with reasonably high yield, and has been demonstrated to visualize tau pathologies in AD and non-AD dementias.1) An exploratory clinical PET study also indicated the capability of [11C]PBB3 in pursuing tau accumulation spreading in progression from prodromal to advanced stages of AD.1) Moreover, [11C]PBB3 binds to tau inclusions in transgenic mouse models of tau pathologies,1) enabling translational research and development of diagnostic and therapeutic drug candidates targeting tau lesions. To avoid conversion to its photoisomers, radiosynthesis and injection of [11C]PBB3 should be performed in a dimly lit facility.2)

References
1) Maruyama et al. Neuron 79, 1094 – 1108, 2013.
2) Hashimoto et al. J Nucl Med 55, 1532-1538, 2014.

Legend for figure

Coronal PET images of brains healthy control (HC) and patient with Alzheimer's disease (AD) at 30 – 70 min after intravenous administration of [11C]PBB3. PET data are superimposed on individual 3D MRI anatomical maps. Intense radiosignals are observed in tau-rich regions including the bilateral hippocampal formations (arrowheads) of the AD brain. Images provided by National Institute of Radiological Sciences.

Catalogue No. NC003-0 & NC006-0

Reagents for 11C radiochemistry of high specific radioactivity

Background of NARD Institute, Ltd.

NARD Institute, Ltd. was established in 1972 by creating a new business model called contract research company in the field of chemistry in Japan. We have started synthesis of specially-ordered PET chemicals since 1995, and have accumulated the synthetic experiences of many precursors and cold standard compounds.
Furthermore, in 2006 we entered into the business tie-up with PharmaSynth AS (Estonia) and since then we have been developing business of distributing PET chemicals that have been produced by both companies, on the global market. Both companies have currently been distributing PET / SPECT precursors that are for general use, as well as cold standard compounds.

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NARD INSTITUTE, LTD. Corporate Group

5-4-1, Minatojimaminami-machi, Chuou-ku, Kobe, Hyogo 650-0047 Japan, JAPAN

There are many more examples of our achievements and capabilities. Please feel free to inquire.
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