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Dendrimers are polymer materials that are also called dendritic polymers or branched polymers, and was reported in 1984 by D. A. Tomalia et al. Generally, a dendrimer has such following properties as not being found in the ordinary polymers: monomers, low density, amorphous polymer to provide functionality to the core and shell, capability to produce monomolecular micelles, its diameter being less than 10 nm, capability to encompass other molecules or metals inside micelles, etc. Moreover, as higher-generation dendrimers can be seen to have a globular, molecular structure, allowing induction of many functional groups on its globular structural or molecular surface, these dendrimers have been expected to be novel, highly functional materials in the fields of pharmaceuticals, electronic materials, chemicals and others. Dendrimers are composed of a core, dendritic structure and shell (ends). The shell influences solubility and reactivity, while the core does the size, functionality, and others. There are two methods of dendrimer synthesis; divergent synthesis and convergent synthesis. Divergent synthesis repeat step-wise reaction from the core molecule, increasing dendrites (generation), while convergent methods synthesize in advance dendrons and finally combine the dendrites to the core molecule. Therefore, compared with the ordinary polymers, dendrimers can be easily controlled in structure, allowing multiple molecular designs. From various combination of these components, it is possible to produce compounds of various shapes and sizes. NARD Institute has been implementing contract synthesis as well as contract research of dendrimer raw materials (building blocks), by making the most use of our abundant experiences and technology accumulated in the synthesis of fine chemicals. On demand from a customer, we will be able to assist the customer in creation of such dendrimers as having new functions, by combining the building blocks to the core molecule. One example of 4th and 5th generation dendrimer building blocks:
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